Question: What Is Duration Of Response?

What is overall response rate?

Overall response rate (ORR) is defined as the proportion of patients who have a partial or complete response to therapy; it does not include stable disease and is a direct measure of drug tumoricidal activity..

What is durable response rate?

The primary endpoint was DRR, defined as the rate of objective response (CR/PR) by modified WHO criteria lasting ≥6 months continuously and beginning within the first 12 months of initiating treatment where disease progression was allowed prior to onset of response.

What is failure free survival?

Failure-free survival, defined as the absence of relapse, non-relapse mortality or addition of another systemic therapy, has been proposed as a potential endpoint for clinical trials, but its use has only been reported for single-center studies.

What is disease control rate?

Disease Control Rate (DCR) and Clinical Benefit Rate (CBR) are defined as the percentage of patients with advanced or metastatic cancer who have achieved complete response, partial response and stable disease to a therapeutic intervention in clinical trials of anticancer agents.

What does Recist 1.1 mean?

Response evaluation criteria in solid tumors (RECIST) is a set of published rules that define when tumors in cancer patients improve (“respond”), stay the same (“stabilize”), or worsen (“progress”) during treatment. … This distinction must be made by both the treating physicians and the cancer patients themselves.

What is best overall response rate?

Definition of Best Overall Tumor Response The Best Overall Response (BOR) is the best response recorded from the start of the study treatment until the disease progression/recurrence: Complete Response (CR) upon confirmation at least 4 wks of 1st CR. Partial Response (PR) upon confirmation at least 4 wks of first PR.

What is objective response rate?

When used as a clinical endpoint for clinical trials of cancer treatments, this often called the objective response rate (ORR). The FDA definition of ORR is “the proportion of patients with tumor size reduction of a predefined amount and for a minimum time period.”

What is complete response?

complete response. Listen to pronunciation. (kum-PLEET reh-SPONTS) The disappearance of all signs of cancer in response to treatment. This does not always mean the cancer has been cured.

What is objective response rate in oncology?

The tumor objective response rate (ORR) is the assessment of the tumor burden (TB) after a given treatment in patients with solid tumors and has a long history. The ORR is undoubtedly an important parameter to demonstrate the efficacy of a treatment and it serves as a primary or secondary end-point in clinical trials.

How is overall survival measured?

overall survival. The length of time from either the date of diagnosis or the start of treatment for a disease, such as cancer, that patients diagnosed with the disease are still alive. In a clinical trial, measuring the overall survival is one way to see how well a new treatment works.

What is radiographic progression free survival?

Radiographic progression-free survival (rPFS) as defined by the Prostate Cancer Clinical Trials Working Group 2 (PCWG2) is a candidate end point that represents a clinically meaningful benefit to patients.

What does time to progression mean?

The length of time from the date of diagnosis or the start of treatment for a disease until the disease starts to get worse or spread to other parts of the body. In a clinical trial, measuring the time to progression is one way to see how well a new treatment works. Also called TTP.

What is the difference between progression free survival and overall survival?

Overall survival refers to the fact that the patient has not died from any cause. Thus, in a clinical trial the measure of overall survival would compare the number of patients who had died and the number who had not died. Progression free survival refers to survival without progression of the disease.

What is CR and pR?

pR: Residual tumor status based on the assessment of resected specimens by the pathologist. cR: Residual tumor status based on the local resection and systemic findings.

What is nadir in Recist?

RECIST 1.0 divides lesions into measurable and non-measurable lesions before the start of therapy [3]. … The ‘nadir’, the smallest SLD during treatment, is the reference for assessment of tumour progression.

What does duration of response mean?

Duration of response is the time from response (R) to progression/death (P/D). The existing statistical procedures for DOR are valid when certain model assumptions are correctly specified. 3. Therefore, in a typical report of a clinical study, DOR is summarized descriptively.

What is progression free survival rate?

Publication Details. Progression-free survival (PFS) is defined as the time from random assignment in a clinical trial to disease progression or death from any cause.

What is Post progression survival?

Post-progression survival (PPS) was defined as the survival time following progressive disease (PD) during treatment with nivolumab. In the present study, definition of partial response, stable disease, and PD were based on the RECIST ver.